Publications

Bonsall, M., Yakob, L., Alphey, N., Alphey, L.  Transgenic control of vectors: the effects of interspecific interactions.  Israel Journal of Ecology & Evolution, Vol 56, 2010, pp353-310.

Harris, A., Nimmo, D., McKemey, A., Kelly, N., Scaife, S., Donnelly, C., Beech, C., Petrie, D., Alphey, L.  (2011) Field performance of engineered male mosquitoes.  Nature Biotechnology, published.

Simmons, G., McKemey, A., Morrison, N,. O’Connell, S., Tabashnik, B., Claus, J., Fu, G., Tang, G., Sledge, M., Walker, A., Phillips, C., Miller, E., Rose, R., Staten, R., Donnelly, C., Alphey, L. (2011). Field performance of a genetically engineered strain of pink bollworm. PLoS ONE.  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024110

Bargielowski, I., Nimmo,D., Alphey, L., Koella, J., (2011) Comparison of Life History Characteristics of the GeneticallyModified OX513A Line and a Wild Type Strain of Aedes aegypti http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117796/pdf/pone.0020699.pdf

Alphey, L.S and Beech C.J (2011) Genetically Engineered Insects – Regulatory Progress and Challenges In: Regulation of Agricultural Biotechnology; The United States and Canada. Eds. C.A Wosniak and A. McHughen Springer (in press).

Black, W.C. IV, Alphey, L. and A. A. James.  (2011) Why RIDL is not SIT.  Trends in Parasitology (in press).

Wise De Valdez, M., Nimmo, D., Betz, J., Gong, H., James, A.A., Alphey, L, and Black, W. (2011) Genetic elimination of dengue vector mosquitoes. PNAS, Vol. 108, No. 12, 4772-4775. http://www.pnas.org/content/108/12/4772.full.pdf+html

Alphey N., Bonsall MB. and Alphey L. (2011) Modeling resistance to genetic control of insects, Journal of Theoretical Biology 270(1):42-55.

Dafa’alla, T., Fu. G., Alphey, L. (2010) Use of a regulatory mechanism of sex determination in pest insect control.  J. Genetics, 89(3): 301-305.

Kongmee, M., Nimmo, D., Labbé, G., Beech, C., Grieco, J., Alphey, L. and Achee, N.  (2010)  Irritant and repellent behavioral responses of Aedes aegypti male populations developed for RIDL® disease control strategies.  J. Med. Entomol. 47(6): 1092-1098.

Vontas, J., Ranson, H and Alphey, L. (2010)  Transcriptomics and disease vector control.  BMC Biology 8:52.

Morrison NI, Franz G, Koukidou M, Miller TA, Saccone G, Alphey LS, Beech CJ, Nagaraju J, Simmons GS, Polito LC (2010) Review: Genetic improvements to the sterile insect technique for agricultural pests. Asia Pacific Journal of Molecular Biology and Biotechnology 18(2):275-295.

Labbé GMC, Nimmo DD, Alphey L (2010) piggybac- and PhiC31-Mediated Genetic Transformation of the Asian Tiger Mosquito, Aedes albopictus (Skuse). PLoS Negl Trop Dis 4(8): e788.

McKemey, A., Alphey, L., Koukidou, M., Kramer, A. (2010) Genetic Improvements to SIT for Fruit Fly Control(2010) RIDL SIT Olivefly IOBC.  Integrated Protection of Olive Crops 53: 11- 16.

Alphey, L., Benedict, M.Q., Bellini, R., Clark, G.G., Dame, D.A., Service, M.W. and Dobson, S.L. (2009) Sterile-insect methods for control of mosquito-borne diseases – an analysis. Vector-Borne and Zoonotic Diseases, Vol. 10, Issue 3, 295-311.

Alphey, L., Bourtzis, K. and Miller, T. (2009) Genetically modified insects as a tool for biorational control.  In Biorational Control of Arthropod Pests: Application and Resistance Management, I. Ishaaya and A.R. Horowitz (eds.), Springer, New York. ISBN 978-90-481-2315-5(H).

Fu, G., Lees, R.S., Nimmo, D., Aw, D., Jin, L., Gray, P., Berendonk, T.U., White-Cooper, H., Scaife, S., Phuc, H.K., Marinotti, O., Jasinskiene, N., James, A.A. and Alphey, L. A female-specific flightless phenotype for mosquito control. PNAS, Vol. 107, No. 10, 4550-4554. http://www.pnas.org/content/108/12/4772.full.pdf+html

Beech, CJ., Vasan, SS., Quinlan, MM., Capurro, ML., Alphey, L., Bayard, V., Bouaré, M., Kittayapong, P., Lavery, J.V. Lim, LH., Marrelli, MT., McLeod, MC., Nagaraju, J., Ombongi, K., Othman, RY., Pillai, V., Ramsey, JM., Reuben, R., Rose, RL., Tyagi, B.K. and Mumford, J. (2009) Deployment of innovative genetic vector control strategies: Progress on regulatory and biosafety aspects, capacity building and development of best-practice guidance.  Asia Pacific Journal of Molecular Biology and Biotechnology 17 (3), 75-85.

Mumford, J., Quinlan, MM., Beech, CJ., Alphey, L., Bayard, V., Capurro, ML., Kittayapong, P., Knight, JD., Marrelli, MT., Ombongi, K., Ramsey, JM. and Reuben, R. (2009) MosqGuide: A project to develop best practice guidance for the deployment of innovative genetic vector control strategies for malaria and dengue. Asia Pacific Journal of Molecular Biology and Biotechnology 17 (3) 93-95.

Beech, CJ., Nagaraju, J. , Vasan, SS. , Rose, RI., Othman,RY., Pillai,V., and Saraswathy, TS. (2009) Risk analysis of a hypothetical open field release of a self-limiting transgenic Aedes aegypti mosquito strain to combat dengue. Asia Pacific Journal of Molecular Biology and Biotechnology 17 (3), 99-111.

Wilke, ABB., Nimmo, DD., St John, O., Kojin BB., Capurro, ML., Alphey, L. and Marrelli, MT. (2009)  Genetic enhancements to the sterile insect technique to control mosquito populations.  Asia Pacific Journal of Molecular Biology and Biotechnology Vol. 17 (3), 65-74.

Morrison, N., Segura, D.F., Stainton, K.C., Fu, G., Donnelly, C.A and Alphey, L. (2009) Sexual competitiveness of a transgenic sexing strain of the Mediterranean fruit fly, Ceratitis capitata. Entomologia Experimentalis et Applicata 133:146-153.

Alphey, L. (2009) Natural and engineered mosquito immunity. Journal of Biology 8: 40.

Papathanos, P.A., Bossin, H.C., Benedict, M.Q., Catteruccia, F., Malcolm, C.A., Alphey, L. and Crisanti, A. (2009) Sex separation strategies: past experience and new approaches. Malaria Journal 8 (Suppl 2): S5.

Alphey, N, Bonsall, M.B., Alphey, L. (2009) Combining pest control and resistance management: synergy of engineered insects with Bt crops. Journal of Economic Entomology, 102: 717-732.

Condon, K.C., Condon, G.C., Dafa’alla, T.H., Forrester, O.T., Phillips, C.E., Scaife, S. and Alphey, L. (2007). Germ-line transformation of the Mexican Fruit Fly. Insect Molecular Biology, 16: 573-580.

Condon, K.C., Condon, G.C., Dafa’alla, T.H., Fu, G., Phillips, C.E., Jin, L., Gong, P. and Alphey, L. (2007). Genetic sexing through the use of Y-linked transgenes. Insect Biochemistry and Molecular Biology, 37: 1168-1176.

Guidance for Contained Field Trials of Vector Mosquitoes Engineered to Contain a Gene Drive System: Recommendations of a Scientific Working Group (2007). Vector-borne and Zoonotic Diseases, 8: 127-166

Alphey, N., Coleman, P.G., Donnelly, C.A. and Alphey, L. (2007). Managing insecticide resistance by mass release of engineered insects. Journal of Economic Entomology, 100: 1642-1649.

Simmons, G.S., Alphey, L., Vasquez, T., Morrison, N.I., Epton, M.J., Miller, E., Miller, T.A., Staten, R. (2007). Potential use of a conditional lethal transgenic pink bollworm Pectinophora gossypiella in area-wide eradication or suppression programmes. In M.J.B. Vreysen, A.S. Robinson and J. Hendrichs (eds.). Area-Wide Control of Insect Pests: From Research to Field Implementation, Springer, Dordrecht, The Netherlands.

Alphey, L. (2007). Engineering insects for the Sterile Insect Technique. In M.J.B. Vreysen, A.S. Robinson and J. Hendrichs (eds.). Area-Wide Control of Insect Pests: From Research to Field Implementation, Springer, Dordrecht, The Netherlands.

Phuc , H.K., Andreasen, M.H., Burton, R.S., Vass, C., Epton, M.J., Pape, G., Fu, G., Condon, K.C., Scaife, S., Donnelly, C.A., Coleman, P.G., White-Cooper, H. and Alphey, L. (2007) Late-acting dominant lethal genetic systems and mosquito control. BMC Biology. 5:11

Fu, G., Condon, K.C., Epton, M.J., Gong, P., Jin, L., Condon, G.C., Morrison, N.I., Dafa’alla, T. H. and Alphey, L. (2007) Female-specific insect lethality engineered using alternative splicing. Nature Biotech., 25:3

Atkinson, M.P., Su, Z., Alphey, N., Alphey, L.S., Coleman, P.G., Wein, L.M. (2007). Analyzing the control of mosquito-borne diseases y a dominant lethal genetic system. PNAS.104:22.

Dafa’alla, T.H., Condon, G.C., Condon, K.C., Phillips, C.E., Morrison, N.I., Jin, L., Epton, M.J., Fu, G. and Alphey, L. (2006). Transposon-free insertions for insect genetic engineering. Nature Biotech., 24: 820-821.

Marrelli, M.T., Moreira, C.K., Kelly, D., Alphey, L. and Jacobs-Lorena, M. (2006). Mosquito transgenesis: what is the fitness cost? Trends Parasit., u: 197-202.

Nimmo, D.D.,Alphey, L. Meredith, J.M. and Eggleston, P (2006). High efficiency site-specific genetic engineering of the mosquito genome. Insect Molecular Biology, 15: 129-136.

Olson, K.E., Alphey, L., Carlson, J. and James, A.A. (2006). Genetic approaches in Aedes aegypti for control of dengue: an overview. In “Bridging Laboratory and Field Research for Genetic Control of Disease Vectors”, eds Knols, B.G.J. and Louis, C. Springer ISBN: 1-4020-3800-3.

Gong, P., Epton, M.J., Fu, G., Scaife, S., Condon, K.C., Condon, G.C., Morrison, N.I., Dafa’alla, T., Coleman, P.G. and Alphey, L. (2005). A dominant lethal genetic system for autocidal control of the Mediterranean Fruit Fly. Nature Biotech., 23: 453-456.

Coleman, P.G. and Alphey, L. (2004). Genetic control of vector populations: an imminent prospect. Trop. Med. Int. Health, 9: 433-437.

Alphey, L., Beard, B., Billingsley, P., Coetzee, M., Crisanti, A., Curtis, C., Eggleston, P., Godfray, C., Hemingway, J., Jacobs-Lorena, M., James, AA., Kafatos, FC., Mukwaya, LG., Paton, M., Powell, JR., Schneider, W., Scott., TW., Sine, B., Sinden, R., Sinkins. S., Spielman, A., Touré, Y. and Collins, FH. (2002). Malaria control with genetically modified vectors. Science 298: 119-121.

Alphey, L. (2002). Re-engineering the Sterile Insect Technique. Insect Biochem. Mol. Biol., 32: 1243-1247.

Alphey, L. and Andreasen, M.(2002).Dominant lethality and insect population control. Mol. Biochem. Parasitology, 121: 173-178.

Bateson, P., Alphey, L., Bulfield, G., Fisher, E., Goodfellow, P., Keverne, B., McConnell, I., Owen, M., Raff, M., Smith, J., Cooper, R., Craig, J. and Teather, S. (2001). The use of GM animals. The Royal Society.

Alphey, L. (2000) Is RIDL the Answer? ISB News Report May 2000: 8-10.

Thomas, D.T., Donnelly, C.A., Wood, R.J. and Alphey, L.S. (2000). Insect population control using a dominant, repressible, lethal genetic system. Science, 287: 2474-2476.