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Oxitec do Brasil Receives Prestigious Award for Innovation and Impact

      The honour recognises company’s results and contribution to the community   PIRACICABA, Brazil, October, 10th, 2017 – Oxitec do Brasil, a subsidiary of Oxitec Ltd, UK, has been presented with the Empreendetec Award in the enterprise category recognizing the...

List of Oxitec peer-reviewed publications (ordered by year of publication)


Thomas, D.D., Donnelly, C.A., Wood, R.J. and Alphey, L.S.  (2000) Insect population control using a dominant, repressible, lethal genetic system.  Science, 287: 2474-2476. PAYWALL:

Alphey, L.(2000) Is RIDL the Answer?  ISB News Report May 2000: 8-10. OPEN ACCESS:


Bateson, P., Alphey, L.,Bulfield, G., Fisher, E., Goodfellow, P., Keverne, B., McConnell, I., Owen, M., Raff, M., Smith, J., Cooper, R., Craig, J. and Teather, S.  (2001). The use of GM animals.  The Royal Society. OPEN ACCESS:



Alphey, L. and Andreasen, M.(2002).Dominant lethality and insect population control. Mol. Biochem. Parasitology, 121: 173-178. PAYWALL:

Alphey, L. (2002). Re-engineering the Sterile Insect Technique. Insect Biochem. Mol. Biol., 32: 1243-1247. PAYWALL:

Alphey, L., Beard, B., Billingsley, P., Coetzee, M., Crisanti, A., Curtis, C., Eggleston, P., Godfray, C., Hemingway, J., Jacobs-Lorena, M., James, AA., Kafatos, FC., Mukwaya, LG., Paton, M., Powell, JR., Schneider, W., Scott., TW., Sine, B., Sinden, R., Sinkins. S., Spielman, A., Touré, Y. and Collins, FH. (2002) Malaria control with genetically modified vectors.  Science 298: 119-121. PAYWALL:


Nimmo, D., Alphey, L.and Eggleston, P. (2003) Development of targeted Cre-lox integration systems in insects. Proceedings: Fourth International Workshop on Transgenesis and Genomics of Invertebrate Organisms. p103.


Coleman, P.G. and Alphey, L.(2004) Genetic control of vector populations: an imminent prospect.  Trop. Med. Int. Health, 9: 433-437. OPEN ACCESS:


Gong, P., Epton, M.J., Fu, G., Scaife, S., Condon, K.C., Condon, G.C., Morrison, N.I., Dafa’alla, T., Coleman, P.G. and Alphey, L.  (2005). A dominant lethal genetic system for autocidal control of the Mediterranean Fruit Fly.  Nature Biotech., 23: 453-456. PAYWALL:


Olson, K.E., Alphey, L., Carlson, J. and James, A.A. (2006). Genetic approaches in Aedes aegyptifor control of dengue: an overview.  In “Bridging Laboratory and Field Research for Genetic Control of Disease Vectors”, eds Knols, B.G.J. and Louis, C.  Springer ISBN: 1-4020-3800-3. PAYWALL:

Nimmo, D.D., Alphey, L. Meredith, J.M. and Eggleston, P (2006).  High efficiency site-specific genetic engineering of the mosquito genome. Insect Molecular Biology, 15: 129-136. OPEN ACCESS:

Marrelli, M.T., Moreira, C.K., Kelly, D., Alphey, L. and Jacobs-Lorena, M. (2006).  Mosquito transgenesis: what is the fitness cost? Trends Parasit. 22: 197-202. OPEN ACCESS:

Dafa’alla, T.H., Condon, G.C., Condon, K.C., Phillips, C.E., Morrison, N.I., Jin, L., Epton, M.J., Fu, G. and Alphey, L. (2006). Transposon-free insertions for insect genetic engineering.  Nature Biotech, 24: 820-821. OPEN ACCESS:


Fu, G., Condon, K.C., Epton, M.J., Gong, P., Jin, L., Condon, G.C., Morrison, N.I., Dafa’alla, T.H. and Alphey, L. (2007). Female-specific insect lethality engineered using alternative splicing. Nature Biotechnology, 25: 353-357. OPEN ACCESS:

Simmons, G.S., Alphey, L., Vasquez, T., Morrison, N.I., Epton, M.J., Miller, E., Miller, T.A., Staten, R., (2007). Potential Use of a Conditional Lethal Transgenic Pink Bollworm Pectinophora gossypiella in Area-Wide Eradication or Suppression Programmes. In M.J.B. Vreysen, A.S. Robinson and J. Hendrichs (eds.). Area-Wide Control of Insect Pests: From Research to Field Implementation, Springer, Dordrecht, The Netherlands. PAYWALL:

Phuc, H.K., Andreasen, M.H., Burton, R., Vass, C., Epton, M.J., Pape, G., Fu, G., Condon, K.C., Scaife, S., Donnelly, C.A., Coleman, P.G., White-Cooper, H. and Alphey, L. (2007). Late-acting dominant lethal genetic systems and mosquito control.  BMC Biology 5: 11. OPEN ACCESS:

Atkinson, M.P., Su, Z., Alphey, N., Alphey, L.S., Coleman, P.G. and Wein, L.M. (2007). Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system. Proc. Nat’l Acad. Sci. (USA). 104: 9540-9545.  OPEN ACCESS:

Alphey, L. (and others).  (2007). World Health Organisation Scientific Working Group Report on Dengue.  168pp. OPEN ACCESS:

Alphey, N., Coleman, P.G., Donnelly, C.A. and Alphey, L. (2007).  Managing insecticide resistance by mass release of engineered insects.  Journal of Economic Entomology, 100: 1642-1649. PAYWALL:

Condon, K.C., Condon, G.C., Dafa’alla, T.H., Forrester, O.T., Phillips, C.E., Scaife, S. and Alphey, L. (2007). Germ-line transformation of the Mexican Fruit Fly.  Insect Molecular Biology, 16: 573-580. PAYWALL:

Alphey, L. (2007). Genetic improvements to the sterile insect technique.  Entomological Research 37 (Suppl. 1) A53 PAYWALL:

Condon, K.C., Condon, G.C., Dafa’alla, T.H., Fu, G., Phillips, C.E., Jin, L., Gong, P. and Alphey, L. (2007).  Genetic sexing through the use of Y-linked transgenes. Insect Biochemistry and Molecular Biology, 37: 1168-1176. PAYWALL:

[Working Group of 29 incl. Alphey, L.] (2007) Guidance for Contained Field Trials of Vector Mosquitoes Engineered to Contain a Gene Drive System: Recommendations of a Scientific Working Group. Vector-borne and Zoonotic Diseases, 8: 127-166 OPEN ACCESS: ‪‪.



Alphey, L., Nimmo, D., O’Connell, S., and Alphey, N. (2008).  Insect population suppression using engineered insects.  In Aksoy, S (ed.) Transgenesis and the management of vector-borne disease, Landes Bioscience, Austin, Texas, USA. aka Adv. Exp. Med. Biol. 2008 627:93-103. PAYWALL:

Yakob, L., Alphey, L., Bonsall, M.B. (2008) Aedes aegypticontrol: the concomitant roles of competition, space and transgenic technologies.  J. Applied Ecol., 45: 1258-1265 OPEN ACCESS:

Alphey, L., Baker, P, Burton, RS., Condon, GC., Condon, KC., Dafa’alla, TH., Epton, M.J.,  Fu, G., Gong, P., Jin, L., Labbé, G., Morrison, N.I., Nimmo, D.D., O’Connell, S., Phillips, C.E., Plackett, A., Scaife, S. and Woods, A. (2008) Genetic technologies to enhance the Sterile Insect Technique (SIT). Proceedings 7thInternational Symposium on Fruit Flies of Economic Importance10-15 September 2006, Salvador, Brazil p319-326 OPEN ACCESS:

Alphey, N., Coleman, P.G., Donnelly, C.A and Alphey, L. (2008) Using mass-release of engineered insects to manage insecticide resistance. Proceedings 7thInternational Symposium on Fruit Flies of Economic Importance10-15 September 2006, Salvador, Brazil p295-298 OPEN ACCESS:


Alphey, N., Bonsall, M.B., Alphey, L. (2009) Combining pest control and resistance management: synergy of engineered insects with Btcrops. Journal of Economic Entomology, 102: 717-732x PAYWALL:

Alphey, L. (2009) Natural and engineered mosquito immunity. Journal of Biology 8: 40 OPEN ACCESS:

Morrison, N.I., Segura, D.F., Stainton, K.C., Fu, G., Donnelly, C.A. and Alphey, L.S. (2009) Sexual competitiveness of a transgenic sexing strain of the Mediterranean fruit fly, Ceratitis capitata.  Entomologia Experimentalis et Applicata 133: 146-153 PAYWALL:

Alphey, L., Bourtzis, K. and Miller, T. (2009) Genetically modified insects as a tool for biorational control.  In I. Ishaaya and A.R. Horowitz (eds.) Biorational Control of Arthropod Pests: Application and Resistance Management.  Springer, NewYork.   ISBN 978-90-481-2315-5(H) PAYWALL:

Papathanos, P.A., Bossin, H.C., Benedict, M.Q., Catteruccia, F., Malcolm, C.A., Alphey, L. and Crisanti, A. (2009) Sex separation strategies: past experience and new approaches.  Malaria Journal 8 (Suppl 2): S5 PAYWALL:

Beech, CJ., Vasan, SS., Quinlan, MM., Capurro, ML., Alphey, L., Bayard, V., Bouaré, M., Kittayapong, P., Lavery, J.V. Lim, LH., Marrelli, MT., McLeod, MC., Nagaraju, J., Ombongi, K., Othman, RY., Pillai, V., Ramsey, JM., Reuben, R., Rose, RI., Tyagi, B.K. and Mumford, J. (2009) Deployment of innovative genetic vector control strategies: Progress on regulatory and biosafety aspects, capacity building and development of best-practice guidance.  Asia Pacific Journal of Molecular Biology and Biotechnology 17 (3) 73-83 OPEN ACCESS:

Mumford, J., Quinlan, MM., Beech, CJ., Alphey, L., Bayard, V., Capurro, ML., Kittayapong, P., Knight, JD., Marrelli, MT., Ombongi, K., Ramsey, JM. and Reuben, R. (2009) MosqGuide: A project to develop best practice guidance for the deployment of innovative genetic vector control strategies for malaria and dengue. Asia Pacific Journal of Molecular Biology and Biotechnology 17 (3) 91-93 OPEN ACCESS:

Wilke, ABB., Nimmo, DD., St John, O., Kojin BB., Capurro, ML., Alphey, L. and Marrelli, MT. (2009) Genetic enhancements to the sterile insect technique to control mosquito populations.  Asia Pacific Journal of Molecular Biology and Biotechnology Vol. 17 (3), 65-74. OPEN ACCESS:


Alphey, L., Benedict, M.Q., Bellini, R., Clark, G.G., Dame, D.A., Service, M.W. and Dobson, S.L. (2010) Sterile-insect methods for control of mosquito-borne diseases – an analysis. Vector-Borne and Zoonotic Diseases, 10(3):295-311. OPEN ACCESS:

Fu, G., Lees, R.S., Nimmo, D., Aw, D., Jin, L., Gray, P., Berendonk, T.U., White-Cooper, H., Scaife, S., Phuc, H.K., Marinotti, O., Jasinskiene, N., James, A.A. and Alphey, L.  (2010) A female-specific flightless phenotype for mosquito control.  Proc. Nat’l Acad. Sci. (USA) 107 (10):4550-4554 OPEN ACCESS:

Vontas, J., Ranson, H and Alphey, L.  (2010) Transcriptomics and disease vector control.  BMC Biology 8:52 OPEN ACCESS:

Labbé, G.M.C., Nimmo, D.D. and Alphey, L.  (2010)piggyBacand PhiC31-mediated genetic transformation of the Asian tiger mosquito, Aedes albopictus(Skuse).  PLoS Negl Trop Dis, 4:e788 OPEN ACCESS:

Kongmee, M., Nimmo, D., Labbé, G., Beech, C., Grieco, J., Alphey, L. and Achee, N.  (2010) Irritant and repellent behavioral responses of Aedes aegyptimale populations developed for RIDL®disease control strategies.  J. Med. Entomol. 47(6): 1092-1098 PAYWALL:

Dafa’alla, T., Fu. G., Alphey, L. (2010) Use of a regulatory mechanism of sex determination in pest insect control.  J. Genetics, 89(3): 301-305 PAYWALL:

Bonsall, M.B., Yakob, L., Alphey, N. and Alphey, L. (2010) Transgenic control of vectors: the effects of interspecific interactions. Israel Journal of Ecology and Evolution 56: 353-370 PAYWALL:

McKemey AR, Alphey L, Koukidou M, Kramer A. (2010) Genetic improvements to SIT for fruit fly control. IOBC-WPRS Bulletin Vol. 53 p. 11-6. PAYWALL:

Ant, T. H., Koukidou, M. and Alphey, L. (2010) Genetic engineering of the olive fruit fly, Bactrocera oleae, for use in the sterile insect technique (SIT). IOBC-WPRS Bulletin, Vol. 59. PAYWALL:


Alphey, N., Bonsall, M.B. and Alphey, L. (2011) Modeling resistance to genetic control of insects.  J. Theor. Biol. 270(1): 42-55 PAYWALL:

Morrison, N.I., Franz, G., Koukidou, M., Miller, T.A., Saccone, G., Alphey, L.S., Beech, C.J., Nagaraju, J., Simmons, G.S., and Polito, L.C. (2011). Genetic improvements to the Sterile Insect Technique for agricultural pests. Asian-Pacific Journal of Molecular Biology and Biotechnology 18:275-295 OPEN ACCESS:

Wise de Valdez, M.R., Nimmo, D., Betz, J., Gong, H., James, A.A., Alphey, L.*, and Black, W.C., IV (2011). Genetic elimination of dengue vector mosquitoes. Proceedings of the National Academy of Sciences (USA) 108:4772-4775 OPEN ACCESS:

Bargielowski, I., Nimmo, D., Alphey, L., and Koella, J.C. (2011). Comparison of Life History Characteristics of the Genetically Modified OX513A Line and a Wild Type Strain of Aedes aegypti. PLoS ONE6, e20699 OPEN ACCESS:

Simmons, G.S., McKemey, A.R., Morrison, N.I., O’Connell, S., Tabashnik, B.E., Claus, J., Fu, G., Tang, G., Sledge, M., Walker, A.S., Phillips, C.E., Donnelly, C.A. and Alphey, L.  (2011). Field performance of a genetically engineered strain of pink bollworm.  PLoS ONE6, e24110 OPEN ACCESS:

Black, W.C. IV, Alphey, L. and A. A. James.  (2011). Why RIDL is not SIT.  Trends in Parasitology 27(8): 362-370 PAYWALL:

Alphey, N., Alphey, L. and Bonsall, M. B. (2011).  A Model Framework to Estimate Impact and Cost of Genetics-Based Sterile Insect Methods for Dengue Vector Control.  PLoS ONE6:e25384. OPEN ACCESS:

Beech, C.J., Quinlan, M.M., Capurro, M.L., Alphey, L.S. and Mumford, J.D. (2011). Update: Deployment of Innovative Genetic Vector Control Strategies including an update on the MosqGuide Project. Asian Pacific Journal of Molecular Biology and Biotechnology19: 101-106 OPEN ACCESS:

Bargielowski, I., Alphey, L., and Koella, J.C. (2011). Cost of Mating and Insemination Capacity of a Genetically Modified Mosquito Aedes aegyptiOX513A Compared to its Wild Type Counterpart. PLoS ONE, 6, e26086 OPEN ACCESS:

Harris, A.F., Nimmo, D., McKemey, A.R., Kelly, N., Scaife, S., Beech, C., Donnelly, C.A., Petrie, W., and Alphey, L. (2011). Field performance of engineered male mosquitoes. Nature Biotech., 29:1034-1037 PAYWALL:

Morrison, N.I., Walker, A. S., Baxter, I., Harvey-Samuel, T., Hdidi, A. and Alphey, L. (2011). Development of genetic control in the tomato leafminer, Tuta absoluta.IOBC-WPRS Bulletin Vol. 68 (2011) PAYWALL:


Alphey, L. and Beech, C. (2012). Appropriate regulation of GM insects.  PLoS Negl Trop Dis 6, e1496 OPEN ACCESS:

Fu, G., Miles, A. and Alphey, L. (2012). Multiplex detection and SNP genotyping in a single fluorescence channel. PLoS One 7:e30340 OPEN ACCESS:

Wilder-Smith, A.,Renhorn, K.-E., Tissera, H., Abu Bakar, S., Alphey, L, Kittayapong, P., Lindsay, S., Logan, J., Hatz, C., Reiter, P., Rocklöv, J., Byass, P., Louis, V.R., Tozan, Y., Massad, E., Tenorio, A., Lagneau, L., L’Ambert, G., Brooks, D., Wegerdt, J. and Gubler, D. (2012). DengueTools: Innovative tools and strategies for the surveillance and control of dengue, Global Health Action, 5:17273 OPEN ACCESS:

Morrison, N. I. & Alphey, L. (2012). Genetically modified insects for pest control: an update. Outlooks Pest Management, 23:65-68 PAYWALL:

Ant, T., Koukidou, M., Rempoulakis, P., Gong, H.-F., Economopoulos, A., Vontas, J.and Alphey, L.(2012). Control of the olive fruit fly using genetics-enhanced SIT. BMC Biology, 10:51 OPEN ACCESS:

Beech, C.J., Koukidou, M., Morrison, N.I. and Alphey, L. (2012) Genetically Modified Insects: Science, Use, Status and Regulation.  ICGEB Collection of Biosafety Reviews 6:66-124. OPEN ACCESS:

Leftwich, P. T., Edward, D. A., Alphey, L., Gage, M. J. G. and Chapman, T. (2012). Variation in adult sex ratio alters the association between courtship, mating frequency and paternity in the lek-forming fruitfly Ceratitis capitata. J. Evol. Biol 25:1732-1740doi: 10.1111/j.1420-9101.2012.02556.x OPEN ACCESS:

Labbé, G. M. C., Scaife, S., Morgan, S., Curtis, Z. & Alphey, L. (2012). Female-specific flightless (fsRIDL) strains of Ae. albopictusfor mosquito control. PLoS Negl Trop Dis, 6: e1724 OPEN ACCESS:

Martins, S., Naish, N., Walker, A.S., Morrison, N.I., S. Scaife, S., Fu, G., Dafa’alla, T. and Alphey, L.(2012) Germline transformation of the diamondback moth, Plutella xylostellaL., using the piggyBac transposable element. Insect Molecular Biology 21: 414-421doi: 10.1111/j.1365-2583.2012.01146.x OPEN ACCESS:

Harris, A.F., McKemey, A.R., Nimmo, D., Curtis, Z., Black, I., Morgan, S.A., Neira Oviedo, M., Lacroix, R., Naish, N., Morrison, N., Collado, A., Stevenson, J., Scaife, S., Dafa’alla, T., Fu, G., Phillips, C., Miles, A., Raduan, N., Kelly, N., Beech, C., Donnelly, C.A., Petrie, W.D., and Alphey, L. (2012) Successful suppression of a field mosquito population by release of engineered male mosquitoes. Nature Biotech. 30:828-830 PAYWALL:

Bargielowski, I., Kaufmann, C., Alphey, L., Reiter, P. & Koella, J. (2012) Flight performance and teneral energy reserves of two genetically modified and one wild type strain of the yellow fever mosquito, Aedes aegypti(Diptera: Culicidae). Vector Borne Zoonotic Dis,12: 1053-1058 doi:10.1089/vbz.2012.0994 OPEN ACCESS:

Lacroix R., McKemey, A.R., Raduan, N., Lim, K.W., Wong, H.M., Teoh, G.N., Siti R.A.A., Salman, S., Subramaniam, S., Oreenaiza. N., Norhaida H.A.T., Angamuthu, C., Suria, M.M., Lees, R.S., Naish, N., Scaife, S., Gray, P., Labbé, G., Beech, C., Nimmo, D., Alphey, L., Vasan, S.S. , Lee H.L., Nazni, W.A., Shahnaz, M.(2012). Open Field Release of Genetically Engineered Sterile Male Aedes aegypti in Malaysia. PLoS One, 7(8): e42771 OPEN ACCESS:

Alphey, L., Koukidou, M., Ant, T.H., Leftwich, P., Rempoulakis, C., Vontas, J., Economopoulos, A., and Chapman, T. (2012). Genetic improvements to sterile-male control of tephritid fruit flies. TEAM Newsletter 11, 3-8 NOT ONLINE

Alphey, L. and Beech, C. (2012). Genetically Engineered Insects – Regulatory Progress and Challenges.  In “Regulation of Agricultural Biotechnology: The United States and Canada”, eds: Wozniak, C.A. & McHughen, A. Springer PAYWALL:

Morrison, N.I., Simmons, G.S., Fu, G., O’Connell, S., Walker, A.S., Dafa’alla, T., Walters, M., Claus, J., Tang, G., Li, J., Marubbi, T., Epton, M.J., Staten, R.T., Miller, E, Miller, T.A. and Alphey, L. (2012). Engineered repressible lethality for control of the pink bollworm, a lepidopteran pest of cotton. PLoS One, e50922 OPEN ACCESS:

Walters, M., Morrison, N.I., John Claus, J., Tang, G., Phillips, C.E., Young, R., Zink, R.T. and Alphey, L. (2012). Field longevity of a fluorescent protein marker in an engineered strain of the pink bollworm, Pectinophora gossypiella (Saunders).  PLoS One 7, e38547 OPEN ACCESS:

Massonnet-Bruneel, B., Corre-Catelin, N., Lacroix, R., Lees, R.S., Phuc, HK, Nimmo, D., Alphey, L. and Reiter, P. (2012). Fitness of transgenic mosquito Aedes aegyptimales carrying a dominant lethal genetic system.  PLoS One, 8:e62711 OPEN ACCESS:


Lee H.L., Vasan, S., Nazni, W.A., Iswarti, I., Norhaida, H., Selvi, S., Alphey, L. and Shahnaz. M. (2013). Mating compatibility and competitiveness of transgenic and wild type Aedes aegypti(L.) under contained semi-field conditions. Transgenic Research, 22: 47-57 doi: 10.1007/s11248-012-9625-z. PAYWALL:

Facchinelli, L., Valerio, L., Ramsey, J.M., Gould, F., Katz, R., Bond, G., Robert, M.A., Lloyd, A.L., James, A.A., Alphey, L., and Scott, T.W. (2013). Field cage studies and progressive evaluation of genetically-engineered mosquitoes.  PLoS Negl Trop Dis 7, e2001. OPEN ACCESS:

Kevin Gorman (2013) Editorial – Resistance 2011 Pest Management Science. 69 (2) page 149. DOI: 10.1002/ps.3481 PAYWALL:

Harris, C.L., Sanchez-Vargas, I.J., Olson, K.E., Alphey, L., and Fu, G. (2013). Polymerase chain displacement reaction. BioTechniques 54, 93-97. OPEN ACCESS:

Salvemini, M., D’Amato, R.,Petrella, V., Aceto, S., Nimmo, D., Neira, M., Alphey, L., Polito, L.C. and Saccone, G. (2013). The orthologue of the fruitfly sex behaviour gene fruitlessin the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing. PLoS One 8, e48554. OPEN ACCESS:

Wilke, A.B.B., Scaife, S., Alphey, L., and Marrelli, M.T. (2013). DsRed2 transient expression in Culex quinquefasciatusmosquitoes. Mem Inst Oswaldo Cruz 108. OPEN ACCESS:

Oreenaiza, M. N, Wesley, D., Wong, H. M., Teoh, G. N., Khairul, A., Nor Azlina, A. H., Winskill, P., Azahari, A. H., Muhammad, Z. S., Lacroix, R., Scaife, S., McKemey, A. R.,

Beech, C., Alphey, L., Nimmo, D. D., Nazni, W. A.and Lee, H. L. (2012). Oral ingestion of transgenic RIDL Ae. aegyptilarvae has no negative effect on two predator Toxorhynchitesspecies.  PLoS One, 8, e58805. OPEN ACCESS:

Jin, L., Walker, A.S., Fu, G., Harvey-Samuel, T., Dafa’alla, T., Miles, A., Marubbi, T., Granville, D., Humphrey-Jones, N., O’Connell, S., Morrison, N.I. and Alphey, L. (2013). Engineered female-specific lethality for control of pest Lepidoptera. ACS Synthetic Biology, 2: 160-166 PAYWALL:

Tan, A., Fu, G., Li, J., Guo, Q., Li, Z., Niu, B., Meng, Z., Morrison, N.I., Alphey, L.*, and Huang, Y. (2013). A transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori. PNAS 110:6766-6770 OPEN ACCESS:

Alphey, L., McKemey, A., Nimmo, D., Neira Oveido, M., Lacroix, R., Matzen, K., and Beech, C. (2013). Genetic control of Aedesmosquitoes. Pathogens and Global Health107: 170-179 OPEN ACCESS:

Marinotti, O., Jasinskiene, N., Scaife, S., Fu, G., Brown, D., Chowa, K., Fazekas, A., Mattingly, S., Alphey, L., and James, A.A. (2013). Development of a population suppression strain for a vector of human malaria, Anopheles stephensi. Malaria Journal,12:142 OPEN ACCESS:

Brown, D.M., Alphey, L.S., McKemey, A., Beech, C., and James, A.A. (2013). Criteria for identifying and evaluating candidate sites for open-field trials of genetically-engineered mosquitoes. Vector-Borne and Zoonotic Diseases, 14(4):291-299. OPEN ACCESS:


Chandru, A., Ummul, H.A., Lacroix, R., Suria, M.M., Vasan, S.S., Shamala, D.S., Lee, H.L., Murad, S., Sit, N.W., Alphey, L., and Nazni, W.A.(2013). Similar susceptibility to dengue and chikungunya for transgenic and non-transformed Aedes aegypti. PLoS Negl Trop Dis,submitted NOT ONLINE

Alphey, L. (2014). Genetic control of mosquitoes. Annual Review of Entomology 59: 205-224. PAYWALL:

Alphey, L., and Alphey, N. (2014). Five things to know about genetically modified (GM) insects for vector control. PLoS Pathogens 10(3):e1003909. OPEN ACCESS:

Alphey L, Koukidou M, Morrison NI (2014) Conditional dominant Lethals – RIDL. In Benedict, M.Q. (ed.) Transgenic Insects: Techniques and Applications. CABI, Oxfordshire, UK. PAYWALL:

Beech C. Regulatory experience and challenges for the release of GM insects 2014 J. Verbr. Lebensm. 9:1 SupplementDOI 10.1007/s00003-014-0886-8. PAYWALL:

Beech C, Miller T (2014) Risk analysis and the regulation of transgenic insects. InBenedict, M.Q. (ed.) Transgenic Insects: Techniques and Applications. CABI, Oxfordshire, UK. PAYWALL:

Brown DM, Alphey LS, McKemey A, Beech C, James AA. (2014). Criteria for identifying and evaluating candidate sites for open-field trials of genetically engineered mosquitoes.Vector Borne Zoonotic Dis. 14(4):291-9. doi: 10.1089/vbz.2013.1364. OPEN ACCESS:

Carvalho DO, Wilke ABB, Nimmo DD, Naish N, McKemey AR, Gray P, Marrelli MT, Virginio JF, Alphey L, Capurro ML (2014) Mass production of genetically modified Aedes aegyptifor field releases in Brazil. JoVE 83:e3579. OPEN ACCESS:

Harvey-Samuel, T., Ant, T., Morrison, N.I., Gong, H., Alphey, L. (2014) Population-level effects of fitness costs associated with repressible female-lethal transgene insertions in two pest insects. Evolutionary Applications, 7(5):597–606. OPEN ACCESS:

Koukidou M, Alphey L (2014) Practical applications of insects’ sexual development for pest control. Sex Dev. 8(1-3):127-36. doi: 10.1159/000357203. PAYWALL:

Leftwich PT, Koukidou M, Rempoulakis P, Gong H-F, Zacharopoulou A, Chapman T, Economopoulos A, Vontas J, Alphey L (2014). Genetic elimination of field-cage populations of Mediterranean fruit flies. Proc Roy Soc (London) B, 281: 20141372. OPEN ACCESS:

Neira M, Lacroix R, Cáceres L, Kaiser PE, Young J, Pineda L, Black I, Sosa N, Nimmo D, Alphey L, McKemey A. (2014). Estimation of Aedes aegypti(Diptera: Culicidae) population size and adult male survival in an urban area in Panama. Mem Inst Oswaldo Cruz 109(7):879-86. OPEN ACCESS:

Scott MJ, Morrison NI, Simmons GS. (2014) Transgenic approaches for sterile insect control of dipteran livestock pests and lepidopteran crop pests. InBenedict, M.Q. (ed.) Transgenic Insects: Techniques and Applications. CABI, Oxfordshire, UK. PAYWALL:

Winskill P, Harris AF, Morgan SA, Stevenson J, Raduan N, Alphey L, McKemey AR, Donnelly CA. (2014). Genetic control of Aedes aegypti: data-driven modelling to assess the effect of releasing different life stages and the potential for long-term suppression. Parasit Vectors. 13(7):68. doi: 10.1186/1756-3305-7-68. OPEN ACCESS:


Haghighat-Khah RE, Scaife S, Martins S, St John O, Matzen KJ, Morrison N, Alphey L. (2015). Site-Specific Cassette Exchange Systems in the Aedes aegypti Mosquito and the Plutella xylostellaMoth. PLoS One 10(4): e0121097. doi: 10.1371/journal.pone.0121097. OPEN ACCESS:

Winskill P, Carvalho DO, Capurro ML, Alphey L, Donnelly CA, McKemey AR (2015) Dispersal of engineered male Aedes aegypti mosquitoes. PLoS Negl Trop Dis 9(11): e0004156. OPEN ACCESS:

Carvalho DO, McKemey AR, Garziera L, Lacroix R, Donnelly CA, Alphey L, Malavasi A, Capurro ML (2015) Suppression of a field population of Aedes aegyptiin Brazil by sustained release of transgenic male mosquitoes. PLoS Negl Trop Dis 9(7): e0003864. OPEN ACCESS:

Curtis Z, Matzen K, Neira Oviedo M, Nimmo D, Gray P, Winskill P, Locatelli MAF, Jardim WF, Warner S, Alphey L, Beech C (2015) Assessment of the impact of potential tetracycline exposure on the phenotype of Aedes aegyptiOX513A: implications for field use. PLoS Negl Trop Dis 9(8): e0003999. OPEN ACCESS:

Harvey-Samuel T, Morrison NI, Walker AS, Marubbi T, Yao J, Collins HL, Gorman K, Davies TGE, Alphey N, Warner S, Shelton AM, Alphey L (2015) Pest control and resistance management through releases of insects carrying a male-selecting transgene. BMC Biology 13: 49. OPEN ACCESS:

Patil PB, Niranjan Reddy BP, Gorman K, Seshu Reddy KV, Barwale SR, Zehr US, Nimmo D, Naish N, Alphey A (2015) Mating competitiveness and life-table comparisons between transgenic and Indian wild-type Aedes aegypti L. Pest Manag Sci.Jul;71(7):957-65. doi: 10.1002/ps.3873 OPEN ACCESS:


Gorman K, Young J, Pineda L, Márquez R, Sosa N, Bernal D, Torres R, Soto Y, Lacroix R, Naish N, Kaiser P, Tepedino K, Philips G, Kosmann C, Cáceres L (2016) Short-term suppression of Aedes aegyptiusing genetic control does not facilitate Aedes albopictus. Pest Management Science 72(3):618-28. doi: 10.1002/ps.4151. OPEN ACCESS:

Mansor, SM Ummul HA, Lacroix R, Chandru A, Thayan R, Vasan SS, Devi SS, Lee HL, Murad S, Sit NW,Alphey L, Nazni WA (2016) Similar vertical transmission of dengue and chikungunya viruses in a transgenic and a non-transformed Aedes aegypti(L.) laboratory strain. Tropical Biomedicine 33(1): 120-134. OPEN ACCESS:

Gregory M, Alphey L, Morrison NI, Shimeld SM (2016) Insect transformation with piggyBac: getting the number of injections just right. Insect Mol Biol, 25: 259–271. PAYWALL:;jsessionid=3694FE870B60851D03E74F8EF7D18E79.f04t01

Turner G (2016) Self-limiting genetics in insect pest management – Regulatory imbalance in risk characterisation. GMOs in Integrated Plant Production, IOBC-WPRS BulletinVol. 114, pp. 83-90. PAYWALL:


Turner J, Krishna R, Van ‘t Hof AE, Sutton ER, Matzen K, Darby AC (2017) The sequence of a male-specific genome region containing the sex determination switch in Aedes aegypti. Pre-print: bioRxiv 122804. OPEN ACCESS:

Marubbi T, Cassidy C, Miller E, Koukidou M, Martin-Rendon E, Warner S, Loni A, Beech C (2017) Exposure to genetically engineered olive fly (Bactrocera oleae) has no negative impact on three non-target organisms. Scientific Reports 7, 11478. OPEN ACCESS:

Zhou L, Alphey N, Walker AS, Travers LM, Hasan F, Morrison NI, Bonsall MB, Raymond B (2017) Combining the high-dose/refuge strategy and self-limiting transgenic insects in resistance management—a test in experimental mesocosms. Evol Appl. 00:1–12. OPEN ACCESS: